Can Roy's boys move closer to qualification?
The visitors will no doubt be set up to avoid defeat, which would see them maintain control of the group and their odds to top the table come in from 4/11 with Sky Bet.
England to win 1-0, 2-0 or 2-1 have been popular in the Correct Score Group Betting, but Ukraine have kept four clean sheets on the trot and are 7/2 to win to nil.
Indeed, four of the last six meetings between these sides have been won to nil, three of which have been in England’s favour and they’re 3/1 to manage that feat again with the Football League’s title partner, Sky Bet.
England boss Roy Hodgson has injury and suspension worries up front, though, meaning Rickie Lambert looks set to lead the line after netting in both of his international appearances.
The Southampton striker heads the goalscorer betting and is available at 7/1 to score first in our Price Boots, while Frank Lampard is 4/1 to score anytime on his 100th appearance for his country.
Remember, if you haven’t already got a Sky Bet account, you can get a completely free £10 when you join and Colchester United will also get £10 when you make your first deposit.
As well as that, the U's will benefit as you bet throughout the season, so make sure you open your account by clicking HERE.
Odds are subject to change