Szmodics to get game time in latest match.U's: Bransgrove, Carroll, Vincent-Young, Roast, Lokko, O'Donoghue, Brampton, Lapslie, Lawrence, Curtis, Hubble, Szmodics, Drey Wright, Vose, Bonne, Smith
Dominic Vose will also turn out for the U21s, as he pushes for a return to first team action.
The match will see Sammie Szmodics continue his return to fitness as, after a substitute appearance in the weekend win over Fleetwood, he gets more game time in the match against Wednesday.
Their recent unbeaten record came to an end when they lost at Birmingham City last time out, but they will look to begin another sequence in front of their own supporters.
Colchester United's U21s are back in action on Monday night as they take on Sheffield Wednesday at the Weston Homes Community Stadium.