Youngsters head north-west for latest fixture.
U's: Bransgrove, Carroll, Vincent-Young, Kent, Lokko, Roast, Brampton, Eastmond, Curtis, Lawrence, Hubble, Bonne, Sembie-Ferris, Smith, IssaThe match kicks off at 7pm.
The squad also includes Dom Smith (pictured), who made his first team debut against Walsall on Saturday.
Tariq Issa scored a hat-trick in that U18s match and he is included in the U21s squad for the match on Monday evening.
However, they will be hoping to replicate the successes of the U18s, who recently won 5-2 at Crewe.
The U's youngsters have played two matches so far, drawing with Sheffield United and losing to Nottingham Forest.
Colchester United U21s play their third fixture of the season on Monday evening, when they take on Crewe at the Alexandra Stadium.