Gilbey and Gordon available.
Alex Wynter is also in line for his second home debut as the U's look to build on last week's 2-0 win against Peterborough United.
Boss Tony Humes is boosted by the news that Alex Gilbey and Ben Gordon are both fit and included in the weekend squad, having both been absent with ankle injuries in the last couple of weeks.
With Freddie's departure, there's a place in the starting line-up up for grabs for the likes of Rhys Healey and Macauley Bonne, who will hope to step into the goalscoring role at the tip of the U's starting eleven.
Colchester United begin life without Freddie Sears on Saturday with a home game against Walsall at the Weston Homes Community Stadium.