Lapslie returns to match action.
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U21s boss John McGreal has again been able to name a strong squad, and the match sees Tom Lapslie return to match action for the first time since his ankle injury in the first team fixture against Bristol.
The U's were beaten by Huddersfield on Tuesday, but have a chance to put that right when they host the Robins in a 2pm kick-off.
Colchester United's U21s will look to get back to winning ways on Thursday afternoon, when they take on Bristol City at the Weston Homes Community Stadium.