Knee injury sidelines skipper.
It is a blow for the U's captain, having already missed the early part of the season with an ankle injury.
He injured a knee in the build-up to the Port Vale game and had to be replaced by Sammie Szmodics on the U's bench in the 2-1 win.
Szmodics is named in the twenty man squad to take on high flying Walsall, who currently sit second in the League One table.
Owen Garvan, who suffered a knock on Tuesday night, has recovered and is expected to line up against Dean Smith's Saddlers at the Weston Homes Community Stadium.
Frankie Kent is also included, having missed the Port Vale game to recover from an accumulation of knocks received in recent weeks.
U's: Parish, Jones, Olufemi, Kent, Eastman, James, Elokobi, Briggs, Lapslie, Gilbey, Garvan, Edwards, Moncur, Szmodics, Ambrose, Sembie-Ferris, Wright, Harriott, Sordell, Bonne
at the Advance rate!Buy your tickets nowColchester United take on high-flying Walsall on Saturday as they look to push up the table.