Dunne and O'Donoghue make Plymouth tripU's: Walker, Bransgrove, Doyley, O'Donoghue, Wynter, Eastman, Prosser, Brindley, Vincent-Young, Slater, Kamara, Guthrie, Szmodics, Wright, sembie-Ferris, Dunne, Fosu, Bonne, Porter, Johnstone.
There are no new injury worries for John McGreal but he will still be without the likes of Doug Loft, Tom Lapslie, Brennan Dickenson and Lewis Kinsella for the game in the South West.
Macauley Bonne also scored against Harry Kewell's side, as he gets back in the swing of things following his loan spell at Lincoln City.
O'Donoghue showed up well against a talented Hornets' attack, whilst Dunne scored in what was his first match action after an ankle injury.
Both youngsters impressed in Monday's comeback win at Watford for the U23s and will be hoping for match action at Home Park on Saturday.
The U's face Plymouth Argyle this weekend, with Louis Dunne and Michael O'Donoghue making the trip.