A strong second half display ensured that Crystal Palace ran out winners in the latest U23s game on Monday afternoon.
The U's were in action in London for the second time in three days, following a weekend trip to Fulham.
The home side had taken the lead after 16 minutes, when Levi Lumeka fired one in off the post to break the deadlock.
The U's, who lost Aaron Barnes to injury just after the half hour mark, went on to have the better of the opening 45 minutes and got level just before half time thanks to a calm finish from Eoin McKeown.
All square at the interval, the U's fell behind seven minutes after the restart.
Kian Flanagan showed good feet down the U's right and lifted a curling effort beyond Callum Coulter and into the net.
The U's made their second change on the hour mark, as Sam Cornish was replaced by the returning Ryan Clampin.
The two teams traded possession in the final quarter of the game, but Palace strengthened their hold on the match when Rob Street tucked home at the far post to make it 3-1.
And the home substitute closed the game off in injury time with Palace's fourth, calmly sidefooting home into the bottom corner.
U's: Coulter, Agboola, Cracknell, Forino, Barnes (Hutchinson 35), Cornish (Clampin 60) Miller, Kennedy, Warde, McKeown, Charles