Richard Hall's side have been beaten 2-0 at the JobServe Community Stadium by Bristol City.
The U’s started the brighter, with a couple of chances in the opening twenty minutes.
Ryan Clampin went close with a shot across goal that flashed just wide of the far post, while Miquel Scarlett saw his weak effort collected easily by Wiles-Richards in the away goal.
Freddie Hinds had the first sight of goal for the visitors as he worked the space on the edge of the area before narrowly shooting wide of the far post.
Hinds was in again a couple of minutes later and stung the palms of Vose with a fierce effort that the home ‘keeper had to push away for a corner.
Bristol City had a great chance to take the lead with three minutes to play in the first half when Vince Harper was fouled by Miquel Scarlett in the area, resulting in the referee pointing to the penalty spot.
Freddie Hinds stepped up to take, but was again thwarted by Vose who got down low to his right to push the ball on to the post before his defence was able to clear.
The two sides went into the break goalless in an even contest.
Five minutes into the second half, the deadlock was broken with Bristol City taking the lead. Hinds unselfishly rolled the ball back to Zac Smith on the edge of the area who was able to curl the ball around Bailey Vose and in to the back of the net.
Four minutes later, the lead was doubled by the visitors. The U’s gave the ball away to Hinds in midfield, who sprinted towards goal before calmly slotting the ball post Vose to make it 0-2.
City were unlucky not to be further ahead with twenty minutes to play when Luois Britton broke clear of the defence but smashed the ball against the post with Vose rushing out to meet him.
The U’s tried to break through a noticeably strong defence, but were unable to really test the back line.
As the game entered injury time, the U’s were reduced to ten men when Miquel Scarlett was sent off for reacting to a challenge that Vince Harper had put in.
The U’s stay tenth in the professional development league, with Richard Hall’s side travelling to play Charlton Athletic U23s at Dartford FC.