Hayden Mullins and Alex Dyer will be looking for a reaction from their squad, after suffering a first home defeat in three games on Tuesday night at the hands of Sutton United.
Despite racing into a second-minute lead on Tuesday evening, the U's were beaten by a Sutton United side that moved back into the play-offs with their three points in North Essex.
Freddie Sears was on target to score his fortieth goal for the club, and was unfortunate not to have added to his tally with a couple of other good chances saved and blocked away by the visiting defence.
But the U's will have to put the disappointement of Tuesday night behind them on Saturday afternoon when Scunthorpe visit the JobServe Community Stadium. Neil Cox's side sit bottom of the table, but were boosted by a 2-1 home win last weekend against Crawley Town.
The U's will be without Samson Tovide and Junior Tchamadeu with both suspended after receiving red cards, but they will be boosted by the return of Brendan Wiredu who has served his one game ban for five yellow cards.
Like the U's, Scunthorpe United had a rocky end to the 2020/21 season, seeing them finish just above the relegation zone, Southend finishing just three points behind them at the close of the campaign.
This season, Neil Cox's side have struggled to pick up regular points, with eleven from fourteen games, putting them bottom of the table.
Last weekend's 2-1 home win against Crawley Town was the side's first victory in ten games, going back to the beginning of August, with the Iron yet to claim three points on the road this season.
Jake Scrimshaw netted the winner last weekend, his second of the campaign making him the top scorer in the squad for Saturday's visitors, with seven other players finding the back of the net.
Scunthorpe's issues have come at both ends of the pitch, being the joint lowest scorers in the league, but having conceded the most out of all teams in Sky Bet League Two with twenty-seven hit past them in their fourteen league games.
Last Time We Met
The U's fell to home defeat against Scunthorpe United in January courtesy of an early Alfie Beestin strike. The U's had chanced through Tommy Smith, Noah Chilvers and Cohen Bramall but were unable to capitalise as the visitors took three points.
Match Tickets are on sale for the U's next home fixture, currently available at the MATCHDAY rate from Col U Tickets. Click HERE to purchase your Match Tickets for this weekend's match.
Parking Tickets are also available to purchase from Col U Tickets, click HERE to see how to purchase them.
For more information on the game and what to expect when you arrive at the JobServe Community Stadium, please click HERE.