Sutton United came from a goal down to beat Colchester United in Tuesday evening's fixture at the JobServe Community Stadium.
The U's took the lead in the second minute of the game when Freddie Sears fired home in front of the South Stand, but the visitors were ahead in the thirtieth minute after Tovide had been sent off and given away a penalty.
Ben Goodliffe put the icing on the cake for the visitors with a third goal in the second half, condenming the U's to a first home defeat in three games.
Hayden Mullins opted for two changes to his Colchester United starting eleven, with a further change enforced upon him.
With Brendan Wiredu missing through suspension, Mullins also decided to drop Frank Nouble and Tom Eastman to the bench, replacing them in the starting line up with Miles Welch-Hayes, Gene Kennedy and Samson Tovide, with the latter two making their first league starts.
The U's made a brilliant start in the game, taking the lead inside two minutes in front of the South Stand.
Charlie Daniels delivered a curling ball into the area, that was well controlled by Sears, before the forward turned and placed the ball in the bottom corner with Bouzanis rooted to the spot.
But the visitors came back at the U's almost instantly, with Ajiboye striking towards goal and forcing a good save out of Shamal George.
The U's 'keeper could do nothing about the equaliser from Sutton though, when on fifteen minutes Ajiboye did find a route to goal. A looping cross found its way to the back post and the Sutton winger who bundled the ball home to make it 1-1.
Just a couple of minutes later, Samson Tovide went close to getting his first goal for Colchester United, and putting the U's back in front. A corner from the far side created a goalmouth scramble, with Tovide taking the final shot, although he was unable to find a clear path to goal and only won a corner.
With just under half an hour gone though, the visitors had turned the game on its head. Samson Tovide was sent off for handball, with Sutton awarded a penalty, that was duly dispatched by Robert Milsom to make it 2-1 to the travelling side.
And that was how it would stay until half time. Sutton United were keen and content to keep the ball in order to retain their lead until the break.
Ten minutes into the second half, there were calls for the visitors to be reduced to ten men, when Ben Goodliffe brought down Freddie Sears on the edge of the penalty area, when the U's goalscorer appeared to be clean through.
The referee brandished the Sutton central defender with a yellow card, with Sears' shot going over the bar after a deflection off Luke Hannant.
Sears had another chance to level the scores with an hour played. He picked up a loose ball played across the Sutton defence, and raced towards goal, but was unable to round Bouzanis, whose outstretched leg kept it at 2-1.
It wouldn't stay 2-1 for long, when a minute later the visitors put the ball in the back of the net at the other end of the pitch.
Ben Goodliffe was the man on target to make it 3-1 to the visitors. The central defender got his head to the ball and powered home an effort that George couldn't get a strong enough hand to, putting the visitors into an almost unassailable lead with twenty-nine minutes to go.
Freddie Sears did have the ball in the back of the net again, with ten minutes left to play, but his effort was ruled out for offside. A strong shot from Daniels was parried by Bouzanis, with Sears prodding in the rebound, only for the flag to be raised.
The game finished at 3-1 with the U's suffering a home defeat for the first time in three games. They remain nineteenth with fourteen points going into the weekend's game against Scunthorpe United.
Colchester United starting XI: George, Welch-Hayes, Chambers, Smith, Hannant (Coxe 67'), Skuse, Sears, Chilvers, Kennedy (Nouble 82'), Daniels, Tovide.
Unused subs: Turner, Jasper, Eastman, Dobra, Cooper.
Sutton United starting XI: Bouzanis, Barden (Davis 86'), Rowe, Goodliffe, Ajiboye, Bugiel (Sho-Silva 80'), Olaofe (Wilson 80'), Boldewijn, Kizzy, Milsom, Smith.
Unused subs: House, Wyatt, Randall.