Wayne Brown will take charge of the U's for the first time since being named Interim Head Coach at Salford City this weekend.
Former central defender, Brown has named another former U's player as part of his management team, with Joe Dunne and U23s manager Dave Huzzey standing on the touchline as well.
The U's will be hoping for an upturn in fortunes after parting company with Hayden Mullins and Alex Dyer earlier in the week, and hunting for their first points of the New Year at Salford City.
It was a tough result to take on Tuesday evening, with the U's leading twice but falling to a stoppage time goal from the hosts who took all three points from the fixture.
Brown, Dunne and Huzzey willl be hoping they can galvanise the squad for the trip to Salford City on Saturday, but will be without Jake Turner who returned to Newcastle United after his loan spell. And the new management team will also check on the fitness of Tommy Smith who left the field with an injury on Tuesday evening.
Gary Bowyer's Salford City side will be wanting to move back towards the top seven in League Two on Saturday afternoon, with the Ammies currently sitting four points behind seventh-placed Mansfield Town.
The Ammies will be wanting to make it back-to-back wins after their 1-0 win at Vale Park on Tuesday evening, with Tom Elliott's goal the difference between the two play-off chasing sides.
Like Sutton United, Salford City don't have a player that is far and away the top scorer, with Brandon Thomas-Asante leading the way on six goals.
The forward is trailed by Matthew Lund and Tom Elliott, with five and four goals apiece, but Bowyer's side have twelve different scorers throughout the 2021/22 season, including former U's men Aramide Oteh and Ian Henderson.
But Henderson hasn't played since early November, with the Ammies also likely to be without Conor McAleny who has also sustained an injury, with Ibou Touray at the Africa Cup of Nations with Gambia.
Last Time We Met
Colchester United were defeated by two first half goals when Salford City visited the JobServe Community Stadium earlier in the season. Brandon Thomas-Asante opened the scoring after Shamal George spilled a bouncing effort, with Tom Elliott adding a second before half time.
Tickets for Saturday's trip can be purchased from Salford City's ticketing site. Click HERE for more information and prices for the game at the Peninsula Stadium.