Hayden Mullins' side will be hoping they can turn things around in South London this evening, when fifth place Sutton United host the U's at the VBS Community Stadium.
The U's are still on the search for their first points of the New Year, after suffering a 2-0 home defeat to Barrow on Saturday afternoon.
Mullins' side will now return to South London for the second time in as many weeks, for the rearranged fixture against Sutton united this evening, hoping to exact revenge on the hosts after they dumped the U's out of the Papa John's Trophy.
Colchester United will be boosted by another January signing, with Owura Edwards arriving through the door on Monday from Bristol City, joining on a loan deal that will run until the end of the season.
And Mullins and Dyer seem to have more of a squad to play with now, with the returns of Miles Welch-Hayes and Frank Nouble on Saturday, leaving only Ryan Clampin and Shamal George still sidelined.
Matt Gray's Sutton United will head into this evening's match full of confidence after coming back from 3-1 down against Stevenage on Saturday to claim a ninety-eighth minute equaliser and steal a point at the Lamex Stadium.
Richie Bennett's late strike capped the 3-3 draw against an in-form Boro side, keeping Sutton in the mix for the top three, still just a point behind third placed Northampton Town.
This evening's game represents one of the many rearranged fixtures in the disrupted schedule, and the South London side will be hoping to use it to their advantage and move into third with a win.
Although Gray's side don't have a main goalscorer in their team, their danger comes from throughout their squad with thirteen players all finding the back of the net this season.
David Ajiboye tops the scorers chart with six, but is closely followed by Robert Milsom, Donovan Wilson and Alistair Smith, all sitting on five goals.
Sutton's Aussie 'keeper, Dean Bouzanis sits fourth in the standings for most clean sheets, with nine in twenty-four games, and he will be hoping to make it into double figures this evening.
Last Time We Met
In the last meeting between the two sides, it was Sutton who came out on top - eliminating the U's from the Papa John's Trophy in the process. Freddie Sears' header was sandwiched by a Jake Turner own goal, and Donovan Wilson's second half strike to put the home side into the last eight of the competition.
Click HERE for all the latest ticketing information for this evening's game. The hosts have decided not to stream the match on iFollow, so they only way to watch will be with a ticket to the game.