Final game of the season for youngsters.
Louis Dunne makes his third U21s appearance, whilst there's an opportunity for three triallists to impress Tony Humes and Richard Hall once again.
Given the first team game on Tuesday night, it's a young squad that goes to London.
The match, which was rescheduled from very early in the campaign, kicks off at 2pm as the U's look to finish their Development League season on a high.
Colchester United U21s play their final game of the season on Wednesday afternoon as they take on Crystal Palace at Selhurst Park.